WHAT IS PH?
In addition, obstructive remodelling of the vessel due to microthrombosis-in-situ and plexiform lesion formation further elevates the pulmonary vascular resistance.
Although the exact processes behind the initiation of PAH are, as yet, unknown, the aetiology is multifactorial and a multi-hit hypothesis in the formation of the disease exists. These potential hits include genetic predisposition, co-existing disease and environmental exposure, such as appetite suppressants and amphetamines.