Home - Link
Pulmonary Hypertension - Scottish Pulmonary Vascular Unit - Research Section

 

BASIC SCIENCE RESEARCH

CLINICAL RESEARCH

HIGH ALTITUDE MEDICINE RESEARCH

PUBLICATIONS

........................................

HOME : NEWS

BASIC SCIENCE RESEARCH

 

Complementing patient care and clinical research, the Scottish Pulmonary Vascular Unit has adopted basic science research since the 1990s in an attempt to understand the profound changes of pulmonary arteries in patients with pulmonary hypertension.

Pulmonary hypertension is a rare disorder but is prevalent in patients with chronic hypoxic lung disease. Exposure to persistent hypoxia results in sustained pulmonary hypertension resulting from a combination of hypoxic vasoconstriction and morphological alterations of the pulmonary vascular bed (termed: pulmonary vascular remodelling).

Our unit utilises contemporary molecular biological techniques (such as silencing RNA and gene knockout models) and are experts in cell isolation from sections of pulmonary arteries. Our research aims to understand and address changes in vessel wall make-up on a cellular level which contribute to the pathology of pulmonary hypertension. Translational research is very important within the Scottish Pulmonary Vascular Unit and we are undertaking studies which crosses from bench to bedside with regards to interesting and novel molecules aimed ultimately at disease targeted therapy.

The research within the unit is known worldwide within the pulmonary hypertension community and has collaborations with laboratories from the UK and Europe. We also train scientists to gain BSc, MD and PhD higher degrees.

Our work is funded by medical charities i.e. British Lung Foundation, Chest, Heart and Stroke Scotland and the British Heart Foundation, all of whom actively seek solutions to this medical condition.

 

Staff within the SPVU Laboratory

  • Section Leader - Dr David Welsh
  • PhD Fellow - Dr Colin Church
  • MD Fellow - Dr Lauren Brash
  • MD Fellow ? Dr Neil McGlinchey   

Border
SCOTTISH PULMONARY VASCULAR UNIT - All rights reserved - Clydebank, Scotland - 0141 951 5497 - SPVUnit@gjnh.scot.nhs.uk